The mission of the Partnership is accomplished through eight principle endeavors:​

• Identifying and addressing the unmet health needs of AYA males through evidence-based approaches;
• Improving public awareness and advocacy for the health needs of AYA males;
• Building on promising and successful models to address the needs of AYA males;
• Engaging stakeholders and building partnerships in synergistic efforts to advance AYA male health;
• Developing resources for stakeholders and individuals working with AYA males; 
• Engaging AYA males in advancing their own health and well being;
• Addressing the underlying social determinants of health for AYA males; and
• Promoting health equity for AYA males by building on their strengths.